Programme  May 26, 2021  May 27, 2021  May 28, 2021

Perspectives of stem cells for disease modelling and therapy

Therapy in cerebral stroke / hemorrhage

Spinal cord injury


Stem cells applications in neurodegenerative diseases and spinal cord injury, part I

Nanotechnology and nanomedicine, part I; Neurorestoratology and neuroinflammation, part I

Nauroprotection & neuroregeneration;



IANR Council Board & Journal of Neurorestoratology Editorial Board Meeting



Poster session (short presentation of 2 slides - poster)

Current status in neurodegenerative and neurodevelopmental disorders;

Poster session (short presentation of 2 slides - poster)


Stem cells applications in neurodegenerative diseases and spinal cord injury, part II

Neurorestoratology and neuroinflammation, part II

Microenvironmental impact on neurogeneration and therapeutic properties of stem cells

UTC+01:00 Program                
26 May 2021,  Wednesday
 Opening Ceremony
Anna Sarnowska - Chairman of the Conference
Hongyun Huang  - IANR Founding President
Ziad M. AlZoubi   - IANR President
Memorial lecture
Chair: Leonora Buzanska

Anna Sarnowska  “The best mentors are those who will tell you where to look, but not what to see: in memory of Krystyna Domanska-Janik (Poland)
Plenary lecture
Chair: Anna Sarnowska

Hongyun Huang “Advances in clinical treatment of Neurorestoratology” (China)

10:10 - 12:10
Perspectives of stem cells for disease modelling and therapy
Chair: Anna Sarnowska and Leonora Buzanska

Leonora Buzanska  “Human brain organoids – breakthrough towards modelling and treatment of neural disorders”  (Poland)
Mari Dezawa “Medical innovation by non-tumorigenic reparative pluripotent Muse cells” (Japan)
Zaal Kokaia  “Reprogramming of human somatic cells for reconstruction of stroke-lesioned neuronal network (Sweden)
Elena Chernykh  Neuroreparative potential of macrophages: new opportunities in regenerative medicine” (Russia)

12:10 – 14:00
Stem cells applications in neurodegenerative diseases and spinal cord injury, Part I
Chair: Leonora Buzanska and Anna Sarnowska

Letizia Mazzini  Cell- Based Therapy for ALS: Past, Present and Future(Italy)
Boguslaw Machalinski  “Humoral Response to Autologous hematopoietic Lineage-Negative Cells Administration in Patients with neurodegenerative diseases – novel view on the paracrine effect consolidation" (Poland)
Pavla Jendelova “Spinal cord injury: How can stem cells help" (Czech Republic)
Wojciech Maksymowicz  Expectation of improvement of impaired Central Nervous System function - the purpose of stem cells research” (Poland)
14:00 – 15:00 Lunch
 Poster session
15:00 – 16:00
Poster session (short presentation of 2 slides – poster)
Chair: Monika Szeliga

Chao Cui  “Application Prospect of Neural Stem Cells in the Treatment of Spinal Cord Injury” (China)
Rui Feng  “Effect of olfactory ensheathing cells transplantation on Wnt /β-catenin signaling pathway in rats with spinal cord injury” (China)
Marzena Zychowicz  “Role of mechanotransduction in regulation of immunomodulatory properties of hWJ-MSC and hiPSC-NSC" (Poland) 
Xiaoyan Mao  “Preparation and performance evaluation of electrospinning bilayer nerve conduit based nerve extracellular matrix and PLA-PCL” (China)
Karolina Ziabska  Effect of the HDAC inhibitor - sodium butyrate on complement system activity in rat model of neonatal hypoxia-ischemia” (Poland)
Justyna Gargas  “Neonatal glial culture systems for in vitro modelling of the selected perinatal neurological disorders in physiologically normoxic conditions” (Poland)
Justyna Janowska  “An impact of neonatal hypoxia – ischemia on oligodendrocyte progenitor cell's fate and effect on myelination in developing brain” (Poland)

16:00 – 18:30
Stem cells applications in neurodegenerative diseases and spinal cord injury, Part II
Chair: Leonora Buzanska and Anna Sarnowska

Wise Young  “Neurogenesis Associated with Neurological Recovery” (USA)
Yang D. Teng  “Targeting Recovery Neurobiology Mechanisms to Improve Function after Spinal Cord Injury” (USA)
Teresita Moviglia Brandolino  “Long term evolution after Cellular therapy in Spinal Cord Injury patients" (Argentina)
Dinko Mitrecic  Translation of stem cell technology: which parameters make a difference?" (Croatia)
Gustavo Antonio Moviglia  “Phenotypic Changes observed on tissue specific EC during activation, and on aMSC after the co-culture of it with the activated EC" (Argentina)
UTC+01:00 Program
27 May 2021,  Thursday
08:00 - 10:30
Therapy in cerebral stroke / haemorrhage
Chair: Hongyun Huang, Lin Chen and Natalia Krzesniak
Chao He  “A Clinical Study of High-dose Urokinase Treatment for Hypertension Induced Ventricular Hemorrhage” (China)
Hongyan Han  “Effect of occipital artery - posterior cerebral artery bypass on visual disturbance due to occipital lobe infarction” (China)
Chao Pan  “MicroRNA-451 regulates angiogenesis and neurological recovery after intracerebral hemorrhage by targeting macrophage migration inhibitory factor” (China)
Mengzhou Xue  “Neuroprotection of minocycline via inhibition of EMMPRIN expression following intracerebral hemorrhage in mice” (China)

Panel Discussion
Yongpeng Yu  “Safety and efficacy of tirofiban in ischemic stroke without large-vessel occlusionsnot receiving intravenous thrombolysi: a Randomized Controlled Open-label Trial” (China)
Ping Zhang  “Dl-3-N-butylphthalide promotes angiogenesis in an optimized model of transient ischemic attack in C57BL/6 mice” (China)
Gaigai Li  “Inhibition of autophagy accelerates hematoma clearance via activating SQSTM1/Keap1/Nrf2 signaling pathway after experimental intracerebral hemorrhage” (China)
Fane Kong  Effect of Transcutaneous Vagus Nerve Stimulation on Shoulder - Hand Syndrome after Stroke” (China)
Panel Discussion
10:30 – 11:50
Nanotechnology and nanomedicine, Part I
Chair: Hongyun Huang, Lin Chen and Marzena Zychowicz
Luming Li  “Technology Advances in Deep Brain Stimulation” (China)
Liming  Cheng  “Immunomodulatory Layered Double Hydroxide Nanoparticles Enable Neurogenesis by Targeting TGFBR 2” (China)
Rongrong Zhu  “Function of Layered Double Hydroxide Nanoparticles on maintaining
MESCs pluripotency” (China)
Ken, Kin-Lam Yung  “Nanomatrix mediated specific neural phenotype differentiation of neuronal stem cells for Parkinson's disease treatment” (China) 
Panel Discussion
Natalia Krzesniak  Longer than expected electrophysiological and clinical improvement in patients after reconstructed nerve release with adipose stem cells support. Long term neuropathic pain elimination” (Poland)
Chaoming Weng  “Another Way:  Cases report on nerve repair of Five Movements and Six Qi in Traditional Chinese Medicine” (China)
Xiao Li  “The Native Epineurium Greatly Enhances the Neuro-induction Activity of the Polymeric Material Nerve Conduit” (China)
Tomasz Debski  Bioactive nanofiber-based conduits in a peripheral nerve gap management - an animal model study”  (Poland)

Panel Discussion
 Plenary lecture
 11:50 – 12:20
Chair: Anna Sarnowska
Dafin F. Muresanu "Pharmacological support with multimodal and monomodal drugs in brain neurorestoration and neurorehabilitation" (Romania)
12:20 - 14:00
Neurorestoratology and neuroinflammation, Part I
Chair: Joanna Sypecka and Monika Szeliga
Ekaterina Shevela  Therapeutic effect of soluble factors of M2 phenotype macrophages in children with language impairments” (Russia)
Magdalena Kuzma - Kozakiewicz  „Current clinical pharmacological trials in amyotrophic lateral sclerosis„ (Poland)
Ziad M. Alzoubi  “A paradigm shift in Neuro-diagnostics, utilization of infrared/radiofrequency hybrid technology for detection of CNS abnormalities” (Jordan)
Hooshang Saberi  “Safety of Granulocyte Colony-Stimulating Factor Administration for Non-traumatic Spinal cord myelopathies: An Open-Label, Phase I Study” (Iran)
 14:00 – 15:00 Lunch
IANR Council Board & Journal of Neurorestoratology Editorial Board Meeting
15:00 – 16:50
Current status in neurodegenerative and neurodevelopmental disorders
Chair: Leonora Buzanska and Valery Zayat
Ali Otom  Neuropathic Pain with Special Reference to Spinal Cord Injuries” (Jordan)
Dorota Hoffman-Zacharska  “Torn networks  - common pathways of neurodevelopmental disorders” (Poland)
Michal Stachowiak  “Brain Organoids – expanding on understanding human brain development, schizophrenia and 'Phase Zero' therapies” (USA)
Marcin Majka  Mesenchymal stem cell transplantation overcome drug-resistant epilepsy in children - clinical observation and potential mechanism of action” (Poland)
17:00 – 19:00
Neurorestoratology and neuroinflammation, Part II
Chair: Leonora Buzanska and Valery Zayat
Ping Wu  “Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells” (USA)
Russell Andrews  “Nanotechniques for Neurorestoratology: Nanoscaffolds, Neuroinflammation, and COVID” (USA)
Michael Chopp  “Exosomes in combination with thrombolytic and mechanical thrombectomy for treatment of stroke”  (USA)
Evan Snyder  “Detoxifying & harnessing “inflammo-attraction” to direct therapeutic stem cell migration”  (USA)
UTC+01:00 Program
28 May 2021,  Friday
Plenary lecture
 08:00 - 08:30

08:30 - 10:50

Chair: Hongyun Huang

Kwok-Fai So  “Human adipose tissue - and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?” (China)

Spinal cord injury
Chair: Hongyun Huang, Lin Chen and Valery Zayat

Nan Wang  Notch Signaling Pathway-Mediated-Olfactory Ensheathing Cells Activate  Endogenous Neural Stem Cells after Spinal Cord Injury” (China)
Zuncheng Zheng  A Preliminary Study on the Effect of Bladder Function Reconstruction on the Establishment of Autonomous Bladder after Spinal Cord Injury” (China)
Xijing He  “Motion-preserving cervical joint system implantation for treatment of cervical myelopathy: a first case report” (China)
Fangyong Wang  “Traumatic spinal cord injury caused by low falls and high falls: a comparative study”  (China)
Panel Discussion
Chengjun Li  “EGFR+ neural stem cell-derived exosomal microRNA-210-5p promotes axon regeneration after spinal cord injury via HDAC6/PI3K-AKT-mTOR axis” (China)
Xiaoyu Wang  “Transplantation of olfactory ensheathing cells promotes the  therapeutic effect of neural stem cells on spinal cord injury by  inhibiting necrioptosis” (China)
Chenxi Zhao  “The Role of Ferroptosis in Spinal Cord Injury Microenvironment” (China)
Yong Hu  “Role of somatosensory function rehabilitation in post-spinal cord injury recovery” (China)

Panel Discussion
10:50 – 12:50

Neuroprotection and Neuroregeneration
Chair: Hongyun Huang, Lin Chen and Anna Sarnowska
Kyoung-Suok Cho “New concept of central cord syndrome; Histological and behavioral study after anterior spinal artery occlusion in rat” (South Korea)
Lin Chen  “Unilateral pallidotomy for Meige syndrome: a Retrospective Report of 28 Cases” (China)
Lukui Chen  Exosomes derived from human neural stem cells improve therapeutical ability for ischemic stroke” (China)
Yong Cao  “Exosomal OTULIN from M2 Macrophages Promotes Recovery of Spinal Cord Injury via Regulating WNT Pathway-Mediated Vascular Regeneration” (China)
Zhijian Cheng  “Macrophages in the injured area induces the migration of grafted neural stem cells through MCP-1/CCR2 and ERK pathway” (China)
Ming Li  “Local Targeting of NAD + Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma” (China)
XiaoPing Wang  “Neuro-protective and cell treatments in patients with Wilson's Disease: Chinese experience” (China)

Panel Discussion
12:50 - 13:50

Chair: Monika Szeliga
Yong Hong Zhang  “Treatment of complex foot & ankle deformities combined with neurotrophic deficiency” (China)
Jian Cheng Zang  “Deformity correction and function reconstruction on foot and ankle of Spina Bifida” (China)
Sihe Qin “Surgical treatment for severe flexion deformity of the knee due to Poliomyelitis sequelae” (China)
Panel Discussion
13:50 – 14:30 Lunch
Poster session
14:30 – 15:30

Poster session  (short presentation of 2 slides – poster)
Chair: Marzena Zychowicz

Han Li  “Therapeutic effect of menstrual blood derived endometrial stem cells on neurodegenerative diseases” (China) 
Ting Li  “Xenogeneic decellularized extracellular matrix-based biomaterials for peripheral nerve repair and regeneration” (China)
Sang Ryong Jeon  “Future therapies including CRISPR for Parkinson’s disease beyond stem cell”  (South Korea)
Michal  Liput  “Mitochondria as a target to trace developmental stage-specific response of human cerebral organoids to different oxygen conditions” (Poland)
Klaudia Radoszkiewicz  “Neurogenic and neuroprotective potential of stem/stromal cells derived from adipose tissue” (Poland)
Emilia  Sinderewicz  “Investigation of the interleukin profile in the cerebrospinal fluid of minimal consciousness state patients after mesenchymal stem cell therapy” (Poland)
Aleksandra Zolocinska  Evaluation of neuroprotective properties of adipose-derived stem cells for peripheral nerves damage” (Poland)
 Plenary lecture
 15:30 – 16:00
Chair: Leonora Buzanska

Małgorzata Lewandowska-Szumiel  “Cell-based Therapies – Through the Looking Glass” (Poland)
16:00 – 17:10

17:10 – 18:40

Microenvironmental impact on neuroregeneration and therapeutic properties of stem cells, Part I
Chair: Leonora Buzanska and Valer Zayat
Ali Jawaid  “Pathogenesis of Neuropsychiatric and Neurodegenerative Diseases: From What We Eat to How Our Parents Felt” (Poland)
Malgorzata Skup  Neuroprotection of retinal ganglion cells with AAV2-BDNF pretreatment in a microbead trabecular occulusion model of glaucoma: a support to stem-cell based therapy?" (Poland)
Gerardo Tricarico  “Ozone therapy and stem cells: viewpoint in regeneration, repair, replacement of damaged components, and recovery mechanisms of immune regulation” (Italy)

Microenvironmental impact on neuroregeneration and therapeutic properties of stem cells, Part II
Chair: Anna Sarnowska and Leonora Buzanska

Wioletta Lech  Biomimetic microenvironmental preconditioning enhance neuroprotective properties of human mesenchymal stem cells derived from Wharton's Jelly (WJ-MSCs)” (Poland)
Stefan Rudzinski  “Influence of material acquisition method and culture medium on ADSCs expression of neuroregenerative and neuroprotective factors” (Poland)
Agnieszka Kaminska  Effect of long-term 3D neurosphere culture on WJ-MSC” (Poland)
Daniela Ferrari  Production and characterization of human neural stem cells for clinical applications" (Italy)
Jacek Szczygielski  Hypothermia after traumatic brain damage: mere (or more than) neuroprotection?" (Poland)

Panel Discussion
Closing Ceremony
Wise Young and Anna Sarnowska

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